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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL3
All Species:
22.42
Human Site:
Y252
Identified Species:
37.95
UniProt:
Q8IVW4
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IVW4
NP_001107047.1
592
67514
Y252
P
K
N
A
R
K
K
Y
P
K
L
N
G
L
L
Chimpanzee
Pan troglodytes
XP_517934
592
67566
Y252
P
K
N
A
R
K
K
Y
P
K
L
N
G
L
L
Rhesus Macaque
Macaca mulatta
XP_001108660
592
67612
Y252
P
K
N
A
R
K
K
Y
P
K
L
N
G
L
L
Dog
Lupus familis
XP_850612
456
51739
D175
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8BLF2
595
67720
Y252
P
K
T
A
R
K
K
Y
P
K
L
N
G
L
L
Rat
Rattus norvegicus
Q9JM01
593
67534
Y252
P
K
N
A
R
K
K
Y
P
K
L
N
G
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512927
637
71445
Y252
P
K
N
A
R
K
K
Y
P
K
L
N
G
L
L
Chicken
Gallus gallus
P13863
303
34670
R22
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
Frog
Xenopus laevis
P35567
302
34487
G21
T
Y
G
V
V
Y
K
G
R
H
K
A
T
G
Q
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
V69
N
L
V
N
L
M
E
V
F
R
R
K
R
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P23572
297
34420
G16
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784044
926
104004
F253
V
E
P
L
E
K
R
F
P
T
L
S
G
L
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
G13
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
G13
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.9
67.7
N.A.
80.5
79
N.A.
57.7
25
24.3
31
N.A.
23.4
N.A.
N.A.
30.2
Protein Similarity:
100
99.8
99.6
72.1
N.A.
89.7
87.6
N.A.
68.9
34.9
35.6
43
N.A.
35.1
N.A.
N.A.
44
P-Site Identity:
100
100
100
6.6
N.A.
93.3
100
N.A.
100
20
6.6
6.6
N.A.
6.6
N.A.
N.A.
33.3
P-Site Similarity:
100
100
100
13.3
N.A.
93.3
100
N.A.
100
26.6
6.6
20
N.A.
6.6
N.A.
N.A.
60
Percent
Protein Identity:
N.A.
22.8
N.A.
23.1
N.A.
N.A.
Protein Similarity:
N.A.
33.9
N.A.
33.9
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
43
0
0
0
0
0
0
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% D
% Glu:
0
8
22
8
8
0
22
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% F
% Gly:
0
8
15
0
8
15
8
29
0
0
15
8
65
8
0
% G
% His:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% H
% Ile:
0
8
0
0
15
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
22
43
0
15
0
58
58
0
0
50
8
15
8
8
15
% K
% Leu:
0
8
0
15
8
8
0
0
0
0
50
0
0
50
50
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
36
8
0
0
0
0
0
0
0
43
0
0
8
% N
% Pro:
43
8
8
0
0
0
0
0
50
0
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% Q
% Arg:
0
0
0
0
43
0
8
8
8
8
8
0
8
8
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
8
% S
% Thr:
8
0
8
0
0
8
0
0
22
8
8
8
8
0
0
% T
% Val:
8
15
15
15
15
0
0
8
8
8
0
15
15
0
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
8
0
0
8
8
8
43
0
15
15
0
0
15
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _